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M9460324.TXT
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1994-06-12
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Document 0324
DOCN M9460324
TI Changes in plasma amino acid concentrations in response to HIV-1
infection.
DT 9408
AU Hortin GL; Landt M; Powderly WG; Department of Pathology, University of
Alabama at Birmingham; 35233.
SO Clin Chem. 1994 May;40(5):785-9. Unique Identifier : AIDSLINE
MED/94228692
AB Plasma concentrations of 21 amino acids were determined for 20 control
subjects and 20 subjects infected with human immunodeficiency virus type
1 (HIV). Compared with the control subjects, the HIV-infected group had
lower cystine, tryptophan, and methionine (decreased 67%, 52%, and 32%,
respectively, P < 0.001 for each) and increased taurine (230%, P <
0.001) and lysine concentrations (30%, P < 0.001). Other amino acid
concentrations changed modestly. Amounts of cystine, tryptophan,
methionine, taurine, and lysine did not differ significantly between
subgroups of HIV-infected subjects with > 200 (n = 6) or < 200 (n = 14)
CD4+ lymphocytes per microliter, suggesting that the concentrations
decrease soon after infection and change little thereafter. Activation
of metabolism of cystine to taurine may explain reciprocal changes in
these amino acids and known depletion of cystine and glutathione. The
selective changes in amino acid profiles observed during HIV infection
differ from those recognized for malnutrition or other pathological
processes.
DE Acquired Immunodeficiency Syndrome/*BLOOD Amino Acids/*BLOOD
Cystine/BLOOD Human *HIV-1 Leukocyte Count Lysine/BLOOD
Methionine/BLOOD Support, Non-U.S. Gov't Support, U.S. Gov't, P.H.S.
Taurine/BLOOD Tryptophan/BLOOD T4 Lymphocytes/PATHOLOGY JOURNAL
ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).